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De Seze, J., Deligne, L., Defebvre L., Ferriby, D., Charpentier P., Stojkovic, T., et al. (2004) Neuromeningeal Tuberculosis: Contribution of the Gene Amplification Method to Diagnosis. Revista de Neurología (Paris), 160, 413-418.
https://doi.org/10.1016/S0035-3787(04)70922-4

has been cited by the following article:

• TITLE: Bacteriologically Confirmed Neuromeningeal Tuberculosis at the Hubert Koutoukou Maga National Hospital and University Center in Cotonou: About Two Cases Study and a Review of the Literature

  AUTHORS: Angèle Azon-Kouanou, Kouessi Anthelme Agbodande, Leoubou Roger Samuel Dodo, Mahoutin Semassa Ghislain Missiho, Roberto Dossou Torès Kouassi Prudencio, Delphin Murhula, Marius Doukpo, Eugénie Dansou, Thomas Lokossou, Djimon Marcel Zannou, Fabien Fabien

  KEYWORDS: Neuromeningeal Tuberculosis, HIV Infection, Death, Cotonou

  JOURNAL NAME: Open Journal of Internal Medicine, Vol.10 No.2, May 19, 2020

  ABSTRACT: Introduction: Tuberculosis remains a major public health problem. The damage to the central nervous system is severe. We reported here two cases. Clinical Case 1: A 37-year-old female patient, naively Human Immunodeficiency Virus1 (HIV1)-positive with antiretroviral (ARV) treatment, hospitalized in the Internal Medicine department for altered consciousness in a febrile context. The clinical examination at admission noted a meningeal syndrome. Cytological analysis of the cerebrospinal fluid (CSF) revealed lymphocytic meningitis with 98% lymphocytes for 3634 leukocytes. CSF polymerase chain reaction (PCR) detected Mycobacterium tuberculosis DNA. She was put on anti-tuberculosis treatment. The immediate course was favourable, but a secondary worsening of the clinical picture was the cause of his death. Clinical Case 2: A 34-year-old male patient, naively HIV1-positive with ARV treatment. He is hospitalized in the Multi-Purpose Anaesthesia and Resuscitation Department of the CNHU HKM for altered consciousness in a feverish context. The clinical examination noted a meningeal syndrome. The cytological analysis of the CSF noted 184 leukocytes for 99% lymphocytes. The CSF PCR identified the DNA of Mycobacterium tuberculosis. He was put on anti-tuberculosis treatment. The evolution was marked by his death. Conclusion: The neuromeningeal localization of tuberculosis is a poor prognosis. Co-infection with HIV remains a potential deadly combination.