TITLE:
Pharmacokinetic/Pharmacodynamic Analysis the Probability of Target Attainment of Posaconazole against Mucorales Species in Patients with Mucormycosis
AUTHORS:
Ying Wang, Jingyi Zhao, Yinhui Yao, Junhui Hu, Jiuli Hu, Xu Xiao, Yanwu Zhao
KEYWORDS:
Mote Carlo Simulation, Posaconazole, Mucorales, Mucormycosis
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.11 No.5,
May
15,
2020
ABSTRACT: The objective of this study was to investigate the probability
of target attainment of various posaconazole
dosing regimens against Mucorales species in patients with mucormycosis.
According to pharmacokinetic/pharmacodynamic parameters of posaconazole in
adults, the dosage regimen of posaconazole for mucormycosis included 50, 100, 200 and 400 mg orally
q12h. Monte Carlo Simulation
analysed the published parameters of pharmacokinetics and the MIC values of
mucormycosis in Mucorales species. The results showed that posaconazole did not affect Rhizopus arrhizus and Mucor sp. The optimal dosage of
posaconazole for Rhizopus microsporus and Rhizomucor pusillus was 400 mg orally q12h and the best dosage regimen for Lichtheimia corymbifera was 200 mg orally
q12h. The antifungal activity of posaconazole against mucormycosis was different, and the dosage regimen needs to
adjust according to fungal species.