TITLE:
Bloodstream Bacterial Infection in Neutropenic Acute Leukemia Patients
AUTHORS:
Salwa I. Abedelnasser, Hala F. Mohamed, Asmaa M. Zahran
KEYWORDS:
Bloodstream Infection (BSI), Blood Cultures, Biomarkers, Molecular Techniques
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.11 No.5,
May
13,
2020
ABSTRACT: Objective: The rapid detection of blood stream infection has the potential to not
only improve patient outcomes due to quicker administration of appropriate
antibiotics but also improve antibiotic stewardship by reducing patient exposures to ineffective or unnecessary
broad-spectrum antibiotics. Methods: In this study blood samples
from acute leukemia neutropenic patients (samples under study) and non
neutropenic patients (control) were tested using cultural and non-cultural
based techniques via blood culture, C-reactive
protein (CRP), Erythrocyte sedimentation rate (ESR) and Molecular techniques (bacterial 16S rDNA analysis). Results: About
22% & 15% were shown positive in blood culturing; 94% & 85% were positive for CRP; 86% and 75% were presented by elevation in ESR rate
for the first hour; 94%
and 80% were presented
by elevation in ESR rate for second hour. Treatment response of the positive
cases by blood culture only was found to be 72.7% and 100% not in remission for
samples under study and control respectively. In cases under study there is statistically
significant correlation between culture growth sensitivity and PCR technique
with P value 0.005.