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Juttler, E., Schwab, S., Schmiedek, P., Unterberg, A., Hennerici, M., Woitzik, J., Witte, S., Jenetzky, E. and Hacke, W. (2007) Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): A Randomized, Controlled Trial. Stroke, 38, 2518-2525.
https://doi.org/10.1161/STROKEAHA.107.485649

has been cited by the following article:

• TITLE: Functional Outcomes of Decompressive Hemicraniectomy for Treatment of Malignant Infarctions of the Middle Cerebral Artery

  AUTHORS: Amr Mohsen, Waleed Abbass

  KEYWORDS: Decompressive Hemicraniectomy, Malignant MCA Infarction, Functional Outcome, Modified Rankin Scale

  JOURNAL NAME: Open Journal of Modern Neurosurgery, Vol.10 No.3, May 8, 2020

  ABSTRACT: Introduction: Malignant middle cerebral artery (MCA) infarction is a devastating entity that is associated with up to 80% mortality. Decompressive Hemicraniectomy has been utilized to treat brain swelling and mass effect secondary to these infarctions in an attempt to improve functional outcome. Aim: To evaluate the functional outcome of decompressive hemicraniectomy in management of malignant MCA infarctions. Methods: The study included 30 patients with malignant MCA infarctions operated upon by decompressive hemicraniectomy and duroplasty with pericranium or fascia lata graft in the period from June 2016 to January 2019. Pre-operative neurological condition, associated morbidity, location and extent of the infarction were assessed. Surgery was performed within 48 hours of the onset of stroke or 12 hours within deterioration of conscious level. Pre-operative CT scan as well as sequential post-operative CT was done. Functional outcome was assessed by the modified Rankin Scale (mRS) at the time of discharge and 3 months following surgery. Results: The study included 18 males and 12 females with a mean age of 54.7 years. The pre-operative GCS was Conclusion: Decompressive hemicraniectomy improves functional outcome in cases of malignant MCA infarction. Pre-operative GCS, age, volume of infarction, degree of midline shift, timing of surgery and associated morbidity are the most important factors affecting the outcome.