TITLE:
The Extent of Solubilization of Flurbiprofen and Ketoprofen by Cetyltrimethylammonium Micelles Using Semi-Equilibrium Dialysis
AUTHORS:
Jimmy D. Roach, Ibrahim Laswi, Malik Mushannen, Ali Chaari, Mandy Bondaruk
KEYWORDS:
Flurbiprofen, Ketoprofen, CTAB, Micelle, Solubilization
JOURNAL NAME:
Advances in Materials Physics and Chemistry,
Vol.10 No.4,
April
29,
2020
ABSTRACT: The partitioning of two non-steroidal
anti-inflammatory drugs (NSAIDs), flurbiprofen and ketoprofen, into cationic
cetyltrimethylammonium micelles was investigated using semi-equilibrium
dialysis at 37℃ in phosphate buffered saline. The micellar-water
solubilization equilibrium constants for both NSAIDs, in their deprotonated
forms, were observed to decrease linearly with increasing mole fraction of drug
in micelles. For flurbiprofen, the solubilization constant in the limit as mole
fraction of drug in micelles approaches zero was found to be 11,200 (co = 1 M), while for ketoprofen the value was 1950 (co = 1 M). Using 1H-NMR and UV spectroscopic techniques, the locus of solubilization
for ketoprofen was found to be towards the charged exterior of the micelles, in
the Stern layer, whereas flurbiprofen was found to solubilize more in the
micellar interior.