TITLE:
The Pharmacological Effects of Triterpenoids from Ganoderma lucidum and the Regulation of Its Biosynthesis
AUTHORS:
Siye Chen
KEYWORDS:
Ganoderma lucidum, Ganoderic Acids, Biosynthesis, Pharmacological Effects
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.10 No.2,
April
23,
2020
ABSTRACT: Ganoderma lucidum is a wildly used medicinal
mushroom and has been used in East Asia because of its health-benefit effects. G. lucidum contains various compounds
with different biological activities, which include anti-tumour, anti-viral,
and anti-malaria effect. Ganoderic acid (GA) is a triterpenoid from G. lucidum. The biosynthesis of GA in G. lucidum is induced by stressors including various elicitors or signaling
molecules, and artificially placing elicitors would enhance GA production. In
this paper, bioactivities and potential applications of GAs would be focused,
and the elicitation strategies for GA production are also highlighted based on the fundamental role of ROS, JA, Ca2+ and NO, which would shed light to developing a novel approach to manipulating
the biosynthesis of GA in the future.