TITLE:
Effect of Dexmedetomidine and Remifentanil on Renal Function in Patients Undergoing Bariatric Surgery
AUTHORS:
Antonio Carlos Meinberg, João Pedro Raduan Meinberg, Nathália Simões Artíbale, Pedro Thadeu Galvão Vianna, Idiberto José Zotarelli Filho
KEYWORDS:
Renal Function, Bariatric Surgery, Dexmedetomidine, Remifentanil
JOURNAL NAME:
Open Journal of Anesthesiology,
Vol.10 No.4,
April
14,
2020
ABSTRACT: Background and Objectives: In anesthesia for bariatric surgery, alterations occur in several organs, including the kidney. The objective of this study was to compare the effect of dexmedetomidine and remifentanil on the renal function of morbidly obese patients submitted to bariatric surgery. Methods: Sixty-one patients were studied prospectively and divided randomly into two groups: remifentanil (R) and dexmedetomidine (D). Renal function was evaluated in three phases: before anesthesia (M0), after anesthetic induction (M1) and after surgical incision (M2). Plasma concentrations were determined for glucose, antidiuretic hormone, creatinine, urea, sodium, potassium and osmolarity and urinary concentrations for creatinine, urea, sodium, potassium and osmolarity. Results: Significant differences were found between groups for potassium at M1 (p Conclusions: In both groups, the clearance values fell from moments M0 to M2. This result indicates that renal function of obese patients submitted to bariatric surgery presented a physiological response compatible with the effect of anesthetic-surgical stress. In the group D, creatinine and sodium clearances were elevated at M1. Urinary volume was greater at M2. These results are suggestive of better preservation of renal function.