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• TITLE: Salivary Biomarkers May Be Useful to Assess Stress State in Patients with Lung Cancer Undergoing Chemotherapy

  AUTHORS: Maiko Kitajima, Yuka Noto, Umi Kudo, Mayumi Urushizaka, Toshiko Tomisawa, Chieko Itaki, Kumiko Kawasaki, Hideaki Yamabe, Akihito Hayashi, Shingo Takanashi

  KEYWORDS: Lung Cancer, Chemotherapy, Secretory-IgA, Saliva, Stress Marker

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.2 No.5, November 28, 2011

  ABSTRACT: Objective: As it is important for medical staff to understand the stress state of patients with cancer, this study investigated the stress state in patients with lung cancer undergoing chemotherapy using salivary biomarkers and questionnaires. Materials and Methods: The subjects included 19 men and 9 women, with a mean age of 66.1 ± 7.1 years who received chemotherapy for lung cancer. Salivary samples of the participants were collected before and the 7 day after chemotherapy. Simultaneously, they completed the POMS (profile of mood states) and QOL (quality of life) questionnaires. The salivary cortisol and secretory IgA as stress markers were measured by enzyme immunoassay. Results: The salivary secretory IgA level was significantly higher at the 7th day after chemotherapy than before chemotherapy (p