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Zohoncon, T.M., Djigma, W.F., Ouattara, A.K., Traore, I.M.A., Ouedraogo, R.A., A., T.E.M., Bado, P., Ouedraogo, T.C., Diarra, B., Ilboudo, M., et al. (2020) Mapping of Fourteen High-Risk Human Papillomavirus Genotypes by Molecular Detection in Sexually Active Women in the West African Sub-Region. International Journal of Genetics and Molecular Biology, 12, 11-21.
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TITLE:
Association between Polymorphisms of Glutathione S-Transferase and Progression to Cervical Cancer in Women from Burkina Faso and Mali
AUTHORS:
Teega-Wendé Clarisse Ouedraogo, Florencia Wendkuuni Djigma, Théodora Mahoukèdè Zohoncon, Boureima Idani, Abdoul Karim Ouattara, Pegdwendé Abel Sorgho, Dorcas Obiri-Yeboah, Prosper Bado, Mah Alima Esther Traore, Birama Diarra, Albert Théophane Yonli, Charlemagne Ouedraogo, Jacques Simpore
KEYWORDS:
Glutathione S-Transferase M1-Null, Cervical Cancer, Burkina Faso, Mali
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.8 No.4,
March
31,
2020
ABSTRACT: Although persistence of high-risk human papillomavirus infection is the main risk factor, Glutathione S-Transferase highly polymorphic enzyme involved in the metabolism of xenobiotics, is a good candidate gene. The objective of this study was to compare the polymorphisms of Glutathione S-Transferase M1-null in women with cancerous lesions and without lesions. This study consisted of 322 uterine cervix samples of women from Mali and Burkina Faso with Cervical Intra-epithelial Neoplasia 2 and 3, adenocarcinoma and squamous cell carcinoma and 100 women with no lesions. Human Papillomavirus genotyping was performed by Real-time multiplex Polymerase Chain Reaction. Glutathione S-Transferase gene polymorphisms were determined using conventional Polymerase Chain Reaction followed by migration on agarose gel. A statistically significant association with high relative risks of 10.77 for the development of High grade Superficial or Squamous Intra-epithelial Lesion (95% CI = 5.59 - 20.72; p