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Gong, Y., Slee, R.B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A.M., et al. (2001) LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development. Cell, 107, 513-523.

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• TITLE: LRP5 Affects Homeostasis of the Periodontal Complex

  AUTHORS: Joo-Hyung Kim, Ye-Hyun Kim, Won Hee Lim

  KEYWORDS: LRP5, Periodontal Ligament, Homeostasis

  JOURNAL NAME: Open Journal of Stomatology, Vol.10 No.3, March 17, 2020

  ABSTRACT: Purpose: The signals responsible for homeostasis in the periodontal complex are unclear. The purpose of this study was to evaluate the role of Low-density lipoprotein receptor-related protein 5(LRP5) in this process by removing LRP5, and observing the effects of LRP5 depletion on cells of the periodontal structures. Material and Methods: The function of this LRP5 was evaluated by conditional elimination of the LRP5 gene using an Osteocalcin Cre driver. The OCN-Cre; mice were examined using micro-CT and histology, immunohistochemistry to evaluate the periodontal complex. Results: Elimination of LRP5 in the periodontal complex of OCN-Cre;mice results in a different expression of Fibromodulin in the periodontal ligament space. A decrease in osteoclastic activity was found in the periodontal ligament. Conclusion: Osteoclastic activities are decreased and expression of fibromodulin is decreased, which implies the involvement of LRP5 in homeostasis of the periodontal ligament.