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Soares, A.P., do Espírito Santo, R.F., Line, S.R., Pinto, M., Santos Pde, M., Toralles, M.B., et al. (2016) Bisphosphonates: Pharmacokinetics, Bioavailability, Mechanisms of Action, Clinical Applications in Children, and Effects on Tooth Development. Environmental Toxicology and Pharmacology, 42, 212-217.
https://doi.org/10.1016/j.etap.2016.01.015

has been cited by the following article:

• TITLE: Prevalence of Non-Responders to Both Oral Bisphosphonate Monotherapy and Intravenous Ibandronate in Patients with Postmenopausal Osteoporosis

  AUTHORS: Naohisa Miyakoshi, Yuji Kasukawa, Michio Hongo, Akira Horikawa, Yoichi Shimada

  KEYWORDS: Bone Resorption, Biphosphonates, Ibandronic Acid, Osteoporosis, Prevalence

  JOURNAL NAME: Open Journal of Orthopedics, Vol.10 No.3, March 6, 2020

  ABSTRACT: Objectives: Although bisphosphonates (BPs) are effective for the majority of patients with osteoporosis, some individuals do not adequately respond to these drugs. The objective of this study was to estimate the prevalence of true BP non-responders who showed insufficient response after both oral BPs and intravenous ibandronate. Methods: Among 146 consecutive patients with postmenopausal osteoporosis who received oral BP monotherapy for more than 12 months, insufficient responders to oral BP monotherapy were switched to intravenous ibandronate injection and followed for more than 12 months. Serum N-terminal telopeptide of type I collagen (NTX) and bone alkaline phosphatase (BAP) concentrations were measured. Patients who also showed insufficient response to intravenous ibandronate were defined as true BP non-responders. Insufficient response to BP therapy was evaluated based on the serum NTX reduction cut-off for minimum significant change. Results: Sixty-one patients (41.8%) were diagnosed as oral BP non-responders. Fourteen patients who switched to intravenous ibandronate and had complete data available were used for final analysis. After switching to intravenous ibandronate, both NTX and BAP decreased significantly (p Conclusion: These results estimated that as few as 9% - 15% (i.e., 21.4% - 35.7% of 41.8%) or as many as 24% - 27% (i.e., 57.1% - 64.3% of 41.8%) of patents might be true BP non-responders.