TITLE:
Treatment of Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis
AUTHORS:
Junyi Shi, Ai Shen, Tong Mou, Zhongjun Wu
KEYWORDS:
Hepatocellular Carcinoma, Portal Vein Tumor Thrombosis, Hepatic Arterial Infusion Chemotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.11 No.3,
March
6,
2020
ABSTRACT: The prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is very poor although sorafenib is recommended as the first-line treatment. Therefore, an effective treatment regime is needed for treating HCC with PVTT. This review summarized seven potential treatment regimes which including transarterial chemoembolization (TACE), TACE combined with sorafenib, TACE combined with radiotherapy (RT), hepatectomy, hepatic arterial infusion chemotherapy (HAIC), HAIC combined with sorafenib and HAIC combined with RT in the treatment of HCC with PVTT. In conclusion, hepatectomy or the combination of HAIC and sorafenib may be a more effective modality in the treatment of HCC patients with type I - II PVTT. HAIC combined with or without sorafenib/RT or the combination of RT and TACE is an alternative treatment choice for HCC patients with type III - IV PVTT. Further randomized controlled studies are warranted.