TITLE:
Bilateral Macronodular Adrenal Hyperplasia
AUTHORS:
Annelie Kérékou Hodé, Hubert Dédjan
KEYWORDS:
Hyperplasia, Macronodular, Adrenal, Cushing’s Syndrome, Adrenalectomy, Dexamethasone
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.10 No.2,
February
27,
2020
ABSTRACT: Cushing’s syndrome is the set of clinical manifestations secondary to a chronic excess of glucocorticoids. Bilateral macronodular adrenal hyperplasia with subclinical cortisol secretion is the most common, but its prevalence remains unknown. We describe a case of bilateral macronodular adrenal hyperplasia. This is a 36-year-old female patient who had been consulting for secondary amenorrhea and developing asthenia for 4 months. The clinical examination noted an overweight patient with high blood pressure, facio-trunk obesity, hirsutism and purple stretch marks in the abdomen and thighs. Biologically, hypokalemia at 2.9 meq/l (3.5 - 5.4), normal calcemia at 90 mg/l (85 - 104), fasting blood sugar was 0.84 g/l (0.7 - 1), the tests for minute, low and high dexamethasone suppression test revealed insufficient suppression of cortisol. The cortisoluria collected from the second day to the third day of the high dexamethasone suppression test was at 186 μg/24 h (