TITLE:
Liver Function Tests in Patients of Acute Leukemia before and after Induction Chemotherapy
AUTHORS:
Tahmidul Islam, A. K. M. Shahidur Rahman, Md. Kamrul Hasan, Ferdous Jahan, Manik Chandra Mondal, Sheuly Ferdoushi, Sabrina Alam, Mohammad Kamrul Ahsan, Jannatut Tasnim, Sharaban Tohura
KEYWORDS:
Acute Leukaemia, Alanine Transaminase (ALT), Aspartate Transaminase (AST), Bilirubin, Chemotherapy
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.8 No.2,
February
20,
2020
ABSTRACT: Background: Patients of acute leukemia require careful assessment of liver function prior to start chemotherapy to determine which drugs may be appropriate or to be modified. Post chemotherapy abnormalities of liver function tests may be due to drugs or due to disease process itself. Objective: To evaluate the status of liver function in acute leukemia patients before and after induction chemotherapy. Methodology: This was a prospective cross-sectional study conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka, Bangladesh from January 2017 to December 2017 on fifty (50) newly diagnosed patients of acute leukemia who fulfilled the selection criteria. Blood samples for serum total bilirubin, alanine transaminase (ALT) and aspartate transaminase (AST) were collected before chemotherapy (Day 1) and after induction chemotherapy on 14th day and 30th day. Serum ALT and AST were measured by kinetic method and serum total bilirubin was measured by DMSO method. Data were analyzed and compared by statistical tests. Result: In this study, the mean level of serum total bilirubin before chemotherapy at day 1 was 0.89 ± 0.64 mg/dl. It was significantly (p Conclusion: It is concluded that serum total bilirubin, ALT and AST increase in response to chemotherapeutic drugs during treatment of acute leukemia.