TITLE:
Microwave Irradiation Effect on Intermolecular and Intramolecular Friedel-Crafts Acylation Reaction
AUTHORS:
Yutaka Okada, Arisa Fujitsu
KEYWORDS:
Microwave Irradiation Effect, Friedel-Crafts Reaction, Cyclization
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.10 No.1,
February
13,
2020
ABSTRACT: The effect of microwave irradiation on the intermolecular and
intramolecular Friedel-Crafts
acylation of aromatic compounds was investigated. Microwave irradiation had no
effect on the intermolecular reaction but had an accelerating effect on the intramolecular
reaction. This enhanced intramolecular reactivity that was attributed to the high
probability of close proximity between the reaction sites.