TITLE:
Retrorectal Cystic Hamartoma with Malignant Transformation
AUTHORS:
Andreia Cruz, Sarah Lopes, Maria Leitão, Sónia Carvalho, Olga Sousa, Manuela Machado
KEYWORDS:
Retrorectal Cystic Hamartoma, Tailgut Cyst, Presacral, Malignant Transformation, Adenocarcinoma
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.11 No.1,
January
16,
2020
ABSTRACT: Retrorectal cystic hamartomas are rare congenital
lesions that can undergo malignant transformation, and adenocarcinoma is the
most frequently described histological type. The authors describe a case of a
53-year-old female patient with a localized well-differentiated adenocarcinoma
that developed in a retrorectal cystic
hamartoma. The patient was submitted to surgery (a Kraske procedure),
with an R1 resection, followed by adjuvant radio-chemotherapy. After 23 months
of follow up, the patient remains free from disease recurrence. Given the rarity of this entity, this case allows us
to reflect on the differential diagnosis, therapeutic approach and patients’
follow-up.