TITLE:
Beneficial Effects of Some Nutraceuticals Containing Glucosamine and Antioxidant against CCL4 Induced Brain Injury in Rats
AUTHORS:
Sawsan A. Nasr, Omer O. A. Ahmed-Farid, El-Shaymaa A. Zein-El-Abedeen
KEYWORDS:
CCL4, Glucosamine, Antioxidant and Neurotransmitter
JOURNAL NAME:
Open Journal of Applied Sciences,
Vol.10 No.1,
December
31,
2019
ABSTRACT: The
present study is performed to investigate the effect of two different
glucosamine containing drugs: Drug 1 and Drug 2 (D1 and D2) against CCl4 induced brain damage in
male albino rats. Liverin (AM) was employed in the current study as an antioxidant
reference drug. CCl4 administration caused a significant elevation
in the levels of MDA and NO of brain tissue, in association with a significant
decrease in the antioxidant defense system (GSH, SOD and GPX) that indicated
the induction of oxidative stress in brain tissue. CCl4 administration induced brain injury as manifested by the obtained changes in
neurotransmitter parameter (norepinephrine (NE), Dopamine (DA), Serotonin
(5-HT), and Acetylcholinesterase AChE). The tested nutraceuticals and the
antioxidant drug displayed a significant improvement against the undue effect
of CCl4 via decreasing the brain tissue content of MDA, NO with the
elevation of GSH content. Also, the significant increase in SOD and GPX
enzymatic activity was obtained when compared to CCL4 group. In addition
AM, D1, and D2 have an ameliorative effect on neurotransmitter parameter NE,
DA, 5HT, and AChE. Results of this study suggest that both antioxidant drugs
and tested nutraceuticals palliate the brain injuries through anti-oxidative
effect, with the elimination of the deleterious effect of toxic metabolites of
CCl4 on brain tissue.