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Schmidt, C., Giese, T., Ludwig, B., Menges, M., Schilling, M., Meuer, S.C., Zeuzem, S. and Stallmach, A. (2006) Increased cytokine transcripts in pouchitis reflect the de-gree of inflammation but not the underlying entity. International Journal of Colorectal Disease, 21, 419-426. doi:10.1007/s00384-005-0024-2

has been cited by the following article:

• TITLE: The pathogenesis of primary pouchitis following ileal pouch-anal anastomosis: a review of current hypotheses

  AUTHORS: Sally Bath, Christian P. Selinger, Rupert W.L. Leong

  KEYWORDS: Pouchitis; Ileo-pouch Anal Anastomosis; Pathogenesis

  JOURNAL NAME: Open Journal of Gastroenterology, Vol.1 No.2, November 17, 2011

  ABSTRACT: Primary pouchitis is a common complication of ileal pouch-anal anastomosis following proctocolectomy in patients treated for ulcerative colitis (UC), but is un-usual for those treated for familial adenomatous polyposis (FAP). While a number of theories as to the pathogenesis of this inflammatory condition have been proposed, no single one has been wholly satis-factory. Much research has been devoted to investi-gating a link between the pathogenic factors involved in UC, but not FAP, and those underlying pouchitis. The contribution of sulfate-producing bacteria has also been explored. The role of other intraluminal factors, such as short chain fatty acids and unconju-gated bile salts, has also been investigated. A unifying theory of a multi-step process might explain the pathogenesis of pouchitis, but further research is re-quired to proof causation. It is likely that pouchitis develops as a result of a combination of genetic, im-munological, microbial and metabolic factors. Future insight into the causes of pouchitis may eventually allow for the development of more effective treat-ments.