TITLE:
Influence of coating on the triamcinolone release of alginate chitosan beads for colonic drug delivery
AUTHORS:
Nadir Veiga Vier, Ruth Meri Lucinda-Silva
KEYWORDS:
Alginate; Beads; Chitosan; Colon-Specific Drug Delivery; Triamcinolone
JOURNAL NAME:
Natural Science,
Vol.3 No.11,
November
23,
2011
ABSTRACT: The aim of this study was to evaluate the effect of coating of alginate-chitosan (AL:CS) beads on the colonic drug delivery. The AL:CS systems containing triamcinolone (TC) were coated with the HPMCP and Eudragit? L100 by immersion and by spraying methods. The drug release profile in simulated colonic medium was determined using 5% human fecal content suspension in 0.01 N buffer solution, pH 6.8. The systems coated with HPMCP showed a lower rate of drug delivery in simulated enteric medium. The delivery profile in simulated colonic medium followed zero-order kinetic. The coated systems provided a promising drug-delivery profile for application in colonic drug delivery.