TITLE:
Prevalence and Prognosis of Relapse of Nephroblastoma at the Pediatric Oncology Unit of Bamako
AUTHORS:
F. L. F. Diakité, P. Togo, A. K. Doumbia, F. Traoré, M. Traoré, K. Sacko, C. O. Coulibaly, N. L. Traoré, A. Touré, B. Maiga, L. N. Sidibé, D. Konaté, A. Diall, A. Dembélé, C. O. Coulibaly, C. B. Traoré, B. Togo
KEYWORDS:
Nephroblastoma, Relapse, Mali
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.9 No.4,
December
10,
2019
ABSTRACT: The nephroblastoma is the third pediatric cancer in
Mali, this study aimed to describe the prevalence and prognosis of
nephroblastoma relapses. Methods: It was a descriptive retrospective
study over a 10-year period from January
2005 to March 2015. We collected children aged 0 to 15 years followed for
relapse of nephroblastoma in the pediatric oncology unit of university hospital
center (UHC) Gabriel Toure. Results: The frequency of relapse of
nephroblastoma was 7.4% (19 cases) whose mean age was 42 months with a sex
ratio of 1.3. The relapse occurred before the end of the postoperative course
in 16% of cases (3 patients). It was local recurrence in 52% of cases (10
patients), pulmonary 16% (3 patients), and hepatic 11% (2 patients). According to the SIOP classification, 47% of
patients were diagnosed in stage III (9 patients) and 21% (4 patients) in stage
IV. The tumor was high risk in 37%. Palliative chemotherapy was performed in
63% of the patients (12 patients) and the remaining seven were put on a high
risk diet. The overall survival at 5 years was 21% or 4 patients. Conclusion: Our results showed all the difficulties in the management of nephroblastoma
relapses in our context.