TITLE:
Effects of Streptococcus salivarius K12 on Experimental Periodontitis and Oral Microbiota in Mice
AUTHORS:
Li Zhu, Hui Li, Xueqin Yang, Li Xue, Xin Li, Junrong Du
KEYWORDS:
Alveolar Bone Resorption, Oral Microbiota, Periodontitis, Probiotic, Streptococcus salivarius K12
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.7 No.12,
December
6,
2019
ABSTRACT: Background: Periodontal
diseases comprise a wide range of inflammatory conditions that affect the
supporting structures of the teeth, and may lead to severe periodontal
destruction and even tooth loss.Streptococcus salivarius K12 (S.
salivarius K12), one of oral probiotics, has been reported to be able to
inhibit various potentially deleterious bacteria. This study was the
first time to investigate the effects of S. salivarius K12 on
ligature-induced periodontitis in mice. Methods: A silk ligature was
tied around the second left maxillary molar to establish the model of
periodontitis, and then, mice in group S. salivarius K12 were
administered with S. salivarius K12 (2 x 109 CFU) twice daily for 30 d, the
others were treated with isopyknic water. Results: Administration with S.
salivarius K12 markedly decreased the anaerobic bacteria accumulation on
the teeth, and it also considerably alleviated periodontitis-induced alveolar
bone resorption and attachment loss. Moreover, S. salivarius K12
administration increased the relative species abundance of Gram-positive
bacterium in oral cavity while decreased Gram-negative bacterium, as well as
the diversity of the bacterial community. Conclusion: Oral
administration of the probiotic S. salivarius K12 may mitigate the
alveolar bone resorption and attachment loss of periodontitis by modulating the
oral microbiota.