TITLE:
The Effect of Body Mass Index on Survival in Breast Cancer
AUTHORS:
Aiat Morsy, Samir Shehata
KEYWORDS:
Body Mass Index, Breast Cancer, Obesity, Overweight, Relapse, Mortality
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.10 No.12,
December
3,
2019
ABSTRACT: Background: Obesity is a well-known risk factor for breast
cancer recurrence and poor prognosis. The objective of this study was to
evaluate the effect of body mass index (BMI) on survival in breast cancer
patients. Methods: We performed a retrospective analysis of 50 breast
cancer patients treated in our hospital from January 2012 to December 2013. Patients
were divided according to body mass index when diagnosed into: normal weight
BMI 25 Kg/m2, over weight BMI ≥ 25 Kg/m2 to 2,
obesity BMI ≥ 30 Kg/m2.
In this study the effect of body mass index on progression free survival (PFS)
and overall survival (OS) was evaluated. Results: The disease free survival (DFS) and overall survival
(OS) decreased in overweight and obese patients. Both overweight and obesity
were predictors for increased risks of breast cancer relapse and mortality with
a median disease free survival for overweight 29 mons and obese patients 11
mons and a median overall survival for overweight patients 49 mons and obese
patients 39 mons. Conclusion: Obesity and overweight are associated with poorer
disease free survival and overall survival in patients with breast cancer.