TITLE:
Correlation between Serum Uric Acid Level and Left Ventricular Ejection Fraction in Patients with Congestive Heart Failure
AUTHORS:
Mohamed A. W. Ezzat, Ahmed M. Boghdady, Kassem F. A. Ibrahim, Lotfy H. Abo Dahab
KEYWORDS:
Uric Acid Level, Congestive Heart Failure
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.9 No.11,
November
27,
2019
ABSTRACT: Background: One of the risk factors of congestive heart failure that still under investigations is hyperuricemia. It’s still
debatable whether it’s an independent risk factor or it’s just a consequence of
other disorders associated with cardiovascular diseases like hypertension,
diabetes and dyslipidemia. Objective: The
aim of our study is to elucidate whether in patients with heart failure serum
uric acid level correlates with left ventricular ejection fraction supporting
the possibility that the detection of progressive hyperuricemia in these
patients may be an indicator of deteriorating cardiac function. Methods: We
conducted a prospective study that included 124 studied patients and 26
apparently healthy persons at Coronary care unit and Internal Medicine
Department at Sohag University Hospitals. Studied populations were classified
into; * Group “I”: newly diagnosed heart failure, * Group “II”: decompensated
heart failure on regular treatment, * Group “III”: decompensated heart failure
but stopped their treatment from three months, Group “IV”: control group,
healthy and age-matched subjects. We studied the association between left
ventricular ejection fraction, the severity of congestive heart failure and the
serum uric acid levels and the well-known conventional risk factors. Results: The main finding was the significantly higher
mean serum uric acid levels in patients with congestive heart failure versus
apparently healthy persons with “P value = 0.02”.
When we adjusted the serum uric acid with other significant risk factors in the
univariate analysis which were age, gender and smoking, serum uric acid was an independent risk factor “P value = 0.04”. There was a significant correlation between
serum uric acid level and the severity of congestive heart failure “P value 0.35”. High rates of serum
uric acid levels were recorded in patients with reduced ejection fraction. A
uric acid level of 8.45 mg/dl was found to be the most appropriate cut-off
point with the sensitivity 62% and the
specificity 78.5%. Conclusion: Higher
serum uric acid levels are significantly correlated with the severity of
congestive heart failure and left ventricular ejection fraction. Serum uric
acid is an independent risk factor for congestive heart failure.