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Buxton, M.A., Meraz-Cruz, N., Sánchez, B.N., Foxman, B., Gronlund, C.J., Beltran-Montoya, J., Castillo-Castrejon, M., O’Neill, M.S. and Vadillo-Ortega, F. (2019) Repeated Measures of Cervicovaginal Cytokines during Healthy Pregnancy: Understanding “Normal” Inflammation to Inform Future Screening. American Journal of Perinatology.
https://doi.org/10.1055/s-0039-1685491

has been cited by the following article:

• TITLE: Cervicovaginal Inflammatory Cytokines, Obesity and Inter-Pregnancy Interval Negatively Affect Pregnancy Duration in Pregnant Women at High-Risk for Recurrent Spontaneous Preterm Birth

  AUTHORS: Youssef Abdal Zaher, Adel F. Al-Kholy

  KEYWORDS: Preterm Birth, Inter-Pregnancy Interval, Cervicovaginal Fluid, Cytokines, Body Mass Index, Cervical Cerclage

  JOURNAL NAME: Advances in Reproductive Sciences, Vol.7 No.4, November 25, 2019

  ABSTRACT: Objectives: Evaluation of change of cervicovaginal fluid (CVF) cytokines’ levels during pregnancy and its relation to incidence of preterm birth (PTB). Patients & Methods: Pregnant women with history of PTB and cervical length α (TNF-α) and interleukins (IL)-6 and -10 levels. Study outcomes included differences in cytokines’ levels between samples and groups. Results: Sample-I cytokines’ levels were significantly higher in study than control women. Cytokines’ levels in Sample-II were significantly higher in control, while were significantly lower in study women compared to Sample-I. Sixteen study women had PTB and had significantly higher CVF levels of IL-10 and TNF-α estimated in both samples than women had no PTB. Pregnancy duration was negatively correlated with maternal body mass index (BMI) and cytokines’ levels, while was positively correlated with inter-pregnancy interval (IPI). Cytokines’ levels were positively correlated with BMI and negatively correlated with IPI. Short IPI and high TNF-α levels are negative predictors for pregnancy duration. Conclusion: High BMI, short IPI and high CVF inflammatory cytokines’ levels negatively affect pregnancy duration especially in women with history of recurrent PTB. Early prophylactic CC for women at high-risk of SPTB can modulate local immune disturbance, reduce incidence of SPTB and prolong pregnancy duration.