TITLE:
How to Return the Death Programs of Cancer Cells to Work again and Cure Cancer within a Short Time?
AUTHORS:
Mahmoud Saad Mohamed El-Khodary, Sahar Ezeldien Hasan, Wael A. Hassan, Maather M. El-Lamie, Ismail A. M. Eissa, Waleed F. Khalil, Salah M. Aly
KEYWORDS:
Cancer, Therapeutic Strategy, Accumulation, Detoxification Enzymes, Free Radicals, Antioxidants, H2O2, Glutathione, NF-kB, Sulforaphane, Flavonoid, Cur Cumin
JOURNAL NAME:
CellBio,
Vol.8 No.2,
June
30,
2019
ABSTRACT: Cancer is cell fleeing from death by blocking the intrinsic and extrinsic pathways of cell death programs. In the present work, the experimental formula was designed to remove these blockers. It was applied on 120 Swiss albino mice which were inoculated intraperitoneally and subcutaneously with Ehrlich Ascites Carcinoma cells; 1 × (106) cell/mouse. The activity of the cell death programs of the tumor was detected by measuring the volume of Ascites fluid, counting the number of dead cancer cells, measuring the size of the tumor, detecting the positive reaction of caspase enzyme in cancer cells and presence of macrophages and apoptotic bodies in tumor tissue. The experimental formula succeeded in removing the blockers of the cell death program in cancer cells returning the cell death program to work again.