TITLE:
Preparation of the Rutin-SBA-16 Drug Delivery System
AUTHORS:
Juliana Camila Fischer Karnopp, Teófilo Fernando Mazon Cardoso, Daniel Araujo Gonçalves, Aline Regina Hellman Carollo, Gustavo Rocha de Castro, Adriana Pereira Duarte, Marco Antonio Utrera Martines
KEYWORDS:
Rutin, Controlled Release Systems, Kinetic Study, Mesoporous Silica, Flavonoid
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.11 No.1,
November
11,
2019
ABSTRACT: This study sets out a scheme for a controlled release delivery system using SBA-16 as a carrier matrix and Rutin as a drug (Rutin-SBA-16). Physicochemical characterizations were performed to confirm the structure of the SBA-16 for post-synthesis by scanning electron microscopy (SEM), Transmission Electron Microscopy (TEM) and X-ray Diffraction (XRD). The presence of Rutin-SBA-16 was confirmed by Fourier-transform infrared spectroscopy (FTIR) and Nitrogen adsorption-desorption isotherms at 77 K. The dissolution kinetics was evaluated by the Zero Order, First Order and Higuchi models, and Rutin quantification was carried out by High Performance Liquid Chromatography (HPLC). The best impregnation time, which was 8 hours, adsorbing 284 μg Rutin per mg of silica, and the maximum degree of dissolution occurred in a period of 20 - 25 h. The release kinetics of the Rutin was called Higuchi, and showed high linearity, with a correlation coefficient (R2) of 0.999 compared with 0.905 and 0.980 of the zero order and first order models respectively. The study shows the benefits of Rutin-SBA-16 as a drug delivery system.