TITLE:
Does the Sleep-Related Neurons Modulate the Sensation of Pain under the Use of GA?
AUTHORS:
Yifan Fang, Jiameng Zong, Samuel Kunes
KEYWORDS:
General Anesthetics (GA), Anesthetic Activated Neuron (AANs), Mechanism, Sleep-Related Neurons, Pain Pathway
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.10 No.11,
November
7,
2019
ABSTRACT: General anesthetics (GA) has been discovered for
centuries and was often used in surgeries. However, many patients are dying
from the usage of GA for different reasons. Although scientists are working on
to solve the problems, the mechanism of GA is still a mystery. Recently,
scientists from Duke University found neurons that are active during sleep can
be activated in anesthesia. These neurons are called Anesthetic Activated
Neurons (AANs). This is a massive step
for us to break the mystery. In this paper, we designed an experiment that aims
to reveal one mechanism of GA: the relationship between sleep-related neurons
and sensation of pain under the use of GA. The designed experiment involves
several control groups that consist of mice with different treatments on their
genes and different GA.