Article citationsMore>>

Crouzet, S., Blana, A., Murat, F.J., Pasticier, G., Brown, S.C.W., Conti, G.N., Ganzer, R., Chapet, O., Gelet, A., Chaussy, C.G., Robertson, N.N., Thuroff, S. and Ward, J.F. (2017) Salvage High-Intensity Focused Ultrasound (HIFU) for Locally Recurrent Prostate Cancer after Failed Radiation Therapy: Multi-Institutional Analysis of 418 Patients. BJU International, 119, 896-904.
https://doi.org/10.1111/bju.13766

has been cited by the following article:

• TITLE: Salvage Transrectal High-Intensity Focused Ultrasound Therapy for Patients with Recurrence of Vesico-Urethral Anastomosis after Radical Prostatectomy

  AUTHORS: Mutsuo Hayashi, Tetsutaro Hayashi, Kiyotaka Oka, Keisuke Goto, Ryuhei Kanaoka

  KEYWORDS: High-Intensity Focused Ultrasound (HIFU), Prostate Cancer, Recurrence of Vesicourethral Anastomosis (VUA), Radical Prostatectomy, Salvage Therapy

  JOURNAL NAME: Open Journal of Urology, Vol.9 No.10, October 29, 2019

  ABSTRACT: Background: Salvage radiotherapy has been used as the treatment for patients with local recurrence after radical prostatectomy. However, the therapy is time-consuming and it experiences adverse effects of some kind. Simple and less invasive treatment is highly anticipated. Objectives: To evaluate the outcomes of salvage transrectal high-intensity focused ultrasound (HIFU) therapy for patients with localized recurrence of a vesicourethral anastomosis (VUA) after radical prostatectomy. Material and methods: Sixteen patients with suspected local recurrence of a VUA after prostatectomy were treated with HIFU. All patients had prostate-specific antigen (PSA) failure (>0.2 ng/ml), positive findings of a VUA with biopsy and/or MRI, TRUS and CT, and no distant metastasis by CT, MRI and bone scintigraphy before HIFU. Recurrence after HIFU was determined by PSA failure (>0.2 ng/ml), histological findings, metastasis and start of systemic therapies. Results: HIFU treatments were performed in 16 patients, and followed-up for 7 - 159 months (median 46.5). The pre-HIFU PSA levels ranged from 0.318 to 3.1 ng/ml. Sonication time ranged from 9 - 42 min. All patients had a decline of PSA after HIFU, and 88% of the PSA nadir was Conclusion: HIFU therapy for local recurrence after prostatectomy may become a feasible salvage therapeutic option because of its ease and simple procedure. For salvage HIFU therapy, further research and additional follow-up are required to evaluate and correct the diagnosis of recurrence areas and to provide the sufficient sonication.