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Aller, M.A., Prieto, I., Cruz, A., Losada, M., Arias, J.I., Garcia-Dominguez, J., Argudo, S., Arias, J.L. and Arias, J. (2009) Extrahepatic Cholestasis. In: Aller, M.A. and Arias, J., Eds., Microsurgery in Liver Research, Bentham Scientific, Sharjah, e-Books, 137-156.

has been cited by the following article:

• TITLE: Gut Lymphangiopathy: Adding Fuel to the Fire in Chronic Liver Disease

  AUTHORS: Luis Tresierra, Maria-Angeles Aller, Isabel Prieto, Luis Santamaria, Jaime Arias

  KEYWORDS: Chronic Liver Disease, Lymphangiogenesis, Microsurgery, Collateral LymphaticCirculation

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.10 No.10, October 15, 2019

  ABSTRACT: The splanchnic inflammation inchronic liver disease increases intestinal angiogenesis. In the current study our aim was demonstrating that the small bowel lymphangiogenesis is associated with angiogenesis in chronic cholestasis in the rat. A stereological study of the lymphatic microcirculation in the small intestine was performed in cholestatic rats. Portal enteropathy in cholestasis increases lymphatic microvessels in the mucosa and submucosa layers. Thus, the lymphatic microvessel volume fraction was superior (p -2; p -2; p -2). These alterations predominate in the duodenum (volume fraction: 0.10 ± 0.01 and length density: 33.55 ± 5.98 mm-2) and ileum (volume fraction: 0.16 ± 0.01 and length density: 38.62 ± 6.07 mm-2). This study demonstrates the predominance of an increased lymphangiogenic response in both end sides of the small bowel associated with chronic liver disease. Since the porto-systemic venous collateral circulation in the chronic liver insufficiency is developed in the ends of the gastrointestinal tract, the excessive duodeno-ileal lymphangiogenesis could suggest the development of amesenteric-systemic lymphatic bypass in the chronic portal hypertension.