TITLE:
Study of Cofactors Associated with Precancerous High-Grade Cervical Lesions at the Teaching Hospital Gabriel Touré, 2010 to 2015
AUTHORS:
Fané Seydou, Bocoum Amadou, Sissoko Abdoulaye, Traoré Soumana Oumar, Sanogo Siaka Amara, Mamadou Sima, Kouma Aminata, Traoré Alassane, Tegueté Ibrahima, Traoré Youssouf, Mounkoro Niani
KEYWORDS:
High Grade Dysplasia, Cofactor, Cervical Cancer, Teaching Hospital, Gabriel Touré
JOURNAL NAME:
Surgical Science,
Vol.10 No.9,
September
25,
2019
ABSTRACT: Introduction: High grade dysplasia of the cervix has a high incidence and
can progress to cervical cancer. The aim was to study cofactors associated
with high-grade cervical dysplasia. Methodology: This was a retrospective
case-control study without matching. Women with high grade dysplasia were
the cases while those with a normal screening test represented the controls.
The study took place at the Gabriel Touré University Hospital Center in Bamako.
We included 351 cases and 420 controls. The capture and analysis were
performed using the SPSS 20 software. A univariate and multivariate logistic
regression analysis was performed for the analysis of risk cofactors. The statistical
tests used were the odds ratio and its confidence interval and the statistical
significance threshold was set at p Results: In univariate analysis,
the co-factors statistically significantly associated with the occurrence of
high-grade dysplasia were parity 0.6 (0.5 - 0.9), gestational 0.7 (0.5 - 0.9),
smoking of the spouse 3.4 (1.1 - 11.3), the non-schooling 1.4 (1.2 - 2.1). In
multivariate analysis after adjusting for confounding factors, two co-factors
have significantly increased the risk of high-grade dysplasia: lack of schooling
1.4 (1.2 - 2.0) and polygamy 1.5 (1.4 - 2.5). Conclusion: At the end of this
study, polygamy and lack of schooling were the main risk factors. The prevention
of cervical cancer will go through the education of girls and women
as well as communication for behavioral change and social change.