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Aritomi, H., Yamasaki, Y., Yamada, K., Honda, H. and Koishi, M. (1996) Development of Sustained-Release Formulation of Chlorpheniramine Maleate Using Powder-Coated Micro Sponge Prepared by Dry Impact Blending Method. Yakuzaigaku, 56, 49-56.

has been cited by the following article:

• TITLE: Determination of Saponification Value in Carnuba Wax by USP/NF Residual Titration Method

  AUTHORS: Stephanie Turnbull, Lauren Bradshaw, Yusuf Yildiz

  KEYWORDS: Saponification Value, Carnuba (Cera Carnuba) Wax, United States Pharmacopeia

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.10 No.9, September 20, 2019

  ABSTRACT: Saponification value is defined as mg KOH needed to neutralize free acids and saponify esters in 1 g of the test substance. A search of the literature showed that the standard saponification methods of the U.S. Pharmacopeia, alcoholic potassium hydroxide were the only saponification reagent. The sample to investigate is saponified with an excess of ethanolic potassium hydroxide solution. After finished saponification the remaining excess of potassium hydroxide is determined by residual titration under Titrimetry , with aqueous volumetric hydrochloric acid. In this study, a test for saponification value has been successfully determined in carnuba wax. The average result has been found 90.9 mg KOH/g substance and, % RPD was 1.65%. This is in contradistinction to the U.S. Pharmacopeia/National Formulary (USP/ NF) Method.