TITLE:
Influence of DAP1 Genotype and Psychosocial Factors on Posttraumatic Stress Disorder in Thai Tsunami Survivors: A GxE Approach
AUTHORS:
Nuntika Thavichachart, Prathan Rutchatajumroon, Taisei Mushiroda, Anchalee Prasansuklab, Sookjaroen Tangwongchai, Puangsoi Worakul, Buranee Kanchanatawan, Siriluck Suppapitiporn, Atapol Sughondhabirom, Chutima Roomruangwong, Ongart Charoensook, Wasun Chantratita, Atsushi Takahashi, Michiaki Kubo, Naoyuki Kamatani, Yusuke Nakamura
KEYWORDS:
Death-Associated Protein 1 Gene (DAP1), Gene-by-Environment Interaction (GxE), Genetype, Posttraumatic Stress Disorder (PTSD), Psychosocial Factors, Tsunami
JOURNAL NAME:
Open Journal of Genetics,
Vol.9 No.3,
September
4,
2019
ABSTRACT: Background: Posttraumatic Stress Disorder (PTSD) is a psychiatric disorder found in individuals afflicted by a traumatic event including the natural disaster. “Tsunami” occurred in Andaman coast of Thailand on December 26, 2004, in which 33.6% of survivors were diagnosed as PTSD. This study aimed to explore the single nucleotide polymorphism (SNP). rs267943 genotype is located on chromosome 5 in the intron of the death-associated protein 1 (DAP1) gene and psychosocial factors for PTSD. Methods: Participants (N = 1970) were recruited from volunteers who have complete data both of DAP1 gene and psychosocial factor. Results: Using a binary logistic regression model, significant gene-environment interactions were found for the single nucleotide polymorphism (SNP) rs267943 and psychosocial factors including depression (adj. OR = 6.0, 95% CI = 4.29 - 8.39), neurotic personality (adj. OR = 2.73, 95% CI = 2.18 - 3.42), planning (adj. OR = 1.52, 95% CI = 1.20 - 1.93), use of emotional support (adj. OR = 1.32, 95% CI = 1.21 - 1.94) with statistical significant p Conclusion: This study demonstrated that GxE studies can be utilized to shed light on the origins of PTSD.