TITLE:
Comparative Study of Dose Distribution Homogeneity between 3D-Brachytherapy and Intensity Modulated Radiation Therapy Techniques in Cervix Cancer Tumors
AUTHORS:
Mostafa Elnagger, Hussein A. Motaweh, Kareman Zard
KEYWORDS:
IMRT, 3D-Brachytherapy, Cervical Cancer
JOURNAL NAME:
International Journal of Medical Physics, Clinical Engineering and Radiation Oncology,
Vol.8 No.3,
August
28,
2019
ABSTRACT: Aim: The purpose of this study was to compare the dosimetric results of the
techniques (3D-Brachytherapy and intensity-modulated radiotherapy IMRT)
in patients with locally advanced cervical carcinoma (LACC). Method: There
are 15 patients with locally advanced cervical carcinoma (LACC), after the
completion of external beam radiotherapy (EBRT) for the whole pelvic irradiation
45 Gy/25 fractions, followed by 3D-Brachytherapy 24 Gy per weekly
fractions and 36 Gy of IMRT per 18 fractions. Coverage of targets volume and
doses received by normal tissue were compared in two techniques. Method: 15
patients of LACC treated with 3D-Brachytherapy were selected for this study.
IMRT plans were also created for all the patients. 3D-Brachytherapy and IMRT
plans were compared on the basis of target volume coverage, dose to Organs at
risk (OAR’s), homogeneity index (HI) and conformity index (CI). Results: The
results showed that D90% of HRCTV in the 3D-Brachytherapy was covered
more than D90% of PTV in the IMRT of prescribed dose, the D2CC and the
V60Gy values of Bladder and rectum were significantly lower than in
3D-Brachytherapy. The HI and CI in 3D-Brachytherapy were found better
than IMRT. Conclusion: 3D-Brachytherapy significantly reduced the irradiated
volume of OAR’s and improved dose coverage in tumor volume compared
to that by IMRT.