TITLE:
Evaluation of the Skin Irritation and Sensitization Potential of the Cussons Baby Sensicare Skin Range of Products in Healthy Volunteers
AUTHORS:
Yullya S. Mulyanti, Yuliarni, Busarin Kasemchainan, Partha P. Mitra, Paul Evans, Haryono Hartono
KEYWORDS:
Cussons Baby Sensicare, Skin Irritation, Skin Sensitization, Hypoallergenic, HRIPT, Atopic Skin Care, Eczema Prone Skin Care
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.9 No.3,
August
20,
2019
ABSTRACT: Introduction: The Cussons Baby Sensicare Range is a newly developed set of products specially formulated for newborn, sensitive and eczema prone skin. As such, these products need to be tested to evaluate their skin irritation and sensitization potential before use. The products were evaluated with two separate tests. The first test was conducted in a single-center, within-subject comparison using assessor-blind, randomised human skin irritation patch test (48 hour/96 hour exposure) and conducted on healthy adults with sensitive, atopic skin. The second test was conducted in a single-center, controlled (sterile water), within subject using human repeat-insult patch tests (HRIPTs) and conducted on healthy female Indonesian and Asian adult female subjects, with sensitive skin. The sensitization potential of each product was determined from International Contact Dermatitis Research Group (ICDRG) scores at 30 minutes, 24 hours, 48 hours and 72 hours after patch removal. Skin irritation tests show that all products were significantly lower than the positive control sodium lauryl sulphate (SLS) (p