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Calabrese, M., Agosta, F., Rinaldi, F., Mattisi, I., Grossi, P., Favaretto, A., et al. (2009) Cortical Lesions and Atrophy Associated with Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis. Archives of Neurology, 66, 1144-1150.
https://doi.org/10.1001/archneurol.2009.174

has been cited by the following article:

• TITLE: The Diagnostic Role of Brain MRI in Detection of Multiple Sclerosis Related Cognitive Impairment

  AUTHORS: Mohamed Saad, Maha Bilal, Wael Gabr, Aymen Abd Elnaby

  KEYWORDS: Multiple Sclerosis, Cognitive Impairment, MRI, Cortical Brain Lesion, MS Related CI

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.9 No.8, August 12, 2019

  ABSTRACT: Background: Cognitive impairment (CI) is a common manifestation of multiple sclerosis (MS), which can severely affect patients’ and their families’ life. Early suspicion and detection of CI can improve general medical management of MS patients. Objectives: To correlate MS related CI to cortical brain lesions using brain magnetic resonance imaging (MRI). Materials and Methods: Cognitive impairment was detected using mini mental state examination (MMSE); Neurological examination and brain MRI were performed for all patients. Correlation was calculated between disease cortical burden detected by MRI and CI. Results: Fifty-three patients with proven MS were scanned by brain MRI; 69.8% of them had cognitive impairment diagnosed with MMSE. The presence and severity of cognitive impairment was correlated to cortical brain lesion. Cognitive impairment was not correlated with non-cortical brain lesions or neurological physical disability measured by Expanded Disability Status Scale (EDSS). Conclusions: Presence of brain frontal cortical lesions detected by MRI in MS patients can predict subsequent development of MS-related CI.