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Kacar, K., Rocca, M.A., Copetti, M., Sala, S., Mesaros, S., Stosic, O.T., et al. (2011) Overcoming the Clinical-MR Imaging Paradox of Multiple Sclerosis: MR Imaging Data Assessed with a Random Forest Approach. American Journal of Neuroradiology, 32, 2098-2102.
https://doi.org/10.3174/ajnr.A2864

has been cited by the following article:

• TITLE: The Diagnostic Role of Brain MRI in Detection of Multiple Sclerosis Related Cognitive Impairment

  AUTHORS: Mohamed Saad, Maha Bilal, Wael Gabr, Aymen Abd Elnaby

  KEYWORDS: Multiple Sclerosis, Cognitive Impairment, MRI, Cortical Brain Lesion, MS Related CI

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.9 No.8, August 12, 2019

  ABSTRACT: Background: Cognitive impairment (CI) is a common manifestation of multiple sclerosis (MS), which can severely affect patients’ and their families’ life. Early suspicion and detection of CI can improve general medical management of MS patients. Objectives: To correlate MS related CI to cortical brain lesions using brain magnetic resonance imaging (MRI). Materials and Methods: Cognitive impairment was detected using mini mental state examination (MMSE); Neurological examination and brain MRI were performed for all patients. Correlation was calculated between disease cortical burden detected by MRI and CI. Results: Fifty-three patients with proven MS were scanned by brain MRI; 69.8% of them had cognitive impairment diagnosed with MMSE. The presence and severity of cognitive impairment was correlated to cortical brain lesion. Cognitive impairment was not correlated with non-cortical brain lesions or neurological physical disability measured by Expanded Disability Status Scale (EDSS). Conclusions: Presence of brain frontal cortical lesions detected by MRI in MS patients can predict subsequent development of MS-related CI.