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Chambhar, R.V., Khadse, B.G., Bobde, A.S. and Bahekar, H.R. (2003) Synthesis and Preliminary Evaluation of Some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d] pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno [2,3-d]pyrimidin-4-ones as Antimicrobial Agents. European Journal of Medicinal Chemistry, 38, 89-100.

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• TITLE: Synthesis, Characterization and Anticancer Activity Studies of New Schiff Base Pt (II) Complex

  AUTHORS: Sama A. Al-Aghbari, Omar M. Al-Shuja’a, Rowaida Al-Badani, Abd Al-Wali M. Japir

  KEYWORDS: Schiff Base, Complexes, Platinum, Anticancer Activity

  JOURNAL NAME: Journal of Materials Science and Chemical Engineering, Vol.7 No.8, August 5, 2019

  ABSTRACT: A New Schiff base ligand and its Pt (II) complex were synthesized. The ligand was prepared by condensation of 2-(4-isobutylphenyl)propanehydrazide with 2,3,4-trihydroxy benzaldehyde this novel ligand and its functional group was carefully designed and selected from well-known biological drugs. The structure of the ligand and its Pt-complex have been confirmed by spectroscopic data, i.e. elemental (CHN) analysis, FT-IR, electronic spectra, NMR spectra. The ligand and its Pt-complex were investigated for their in vitro anticancer potential using HeLa and PC3 cells. The Pt-complex showed a higher cytotoxic activity than the ligand towards Hela cells and PC3 cells.