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He, Q., Kong, X., Wu, G., Ren, P., Tang, H., Hao, F., Huang, R., Li, T., Tan, B., Li, P., Tang, Z., Yin, Y. and Wu, Y. (2009) Metabolomics Analysis of the Response of Growing Pigs to Dietary L-Arginine Supplementation. Amino Acids, 37, 199-208.
https://doi.org/10.1007/s00726-008-0192-9

has been cited by the following article:

• TITLE: L-Arginine Supplementation Alters Maternal Blood Biochemical Attributes and Milk Composition Relative to Neonatal Traits of Najdi Ewes

  AUTHORS: Moustafa M. Zeitoun, Ahmed A. Al-Ghoneim, Khalid A. Al-Sobayil, Yasser R. Hassanein, Mohamed M. Mansour, Kheir El-Din M. El-Azrak, Marwa F. A. Attia, Tariq I. Almundarij

  KEYWORDS: L-Arginine, Ewes, Fetus, Metabolites, Lactation, Offspring

  JOURNAL NAME: Open Journal of Animal Sciences, Vol.9 No.3, July 30, 2019

  ABSTRACT: In a 2 × 3 factorial arrangement, 3 levels of L-arginine (0, 75 and 150 mg/kg BW per day) were tested at two stages of pregnancy (Early 60 days vs. Late 60 days) on the maternal blood metabolites and postnatal milk composition relative to the newborn traits of Najdi ewes. Thirty adult pregnant Najdi ewes were randomly assigned into 6 treatments (n = 5). Control early (CE) ewes were orally administered 50 mL normal saline (0.9% NaCl) daily during the first 60 days of pregnancy; control late (CL) ewes were similar to CE except saline was given at the last 60 days of pregnancy; low dose of L-arginine at early pregnancy (LE); low dose of L-arginine at late pregnancy (LL); high dose of L-arginine at early (HE) and high dose of L-arginine at late pregnancy (HL). Blood and milk samples were collected on a weekly basis. Data of lambing and newborn traits were considered. There were non-significant differences in litter size due to L-arginine; however lamb birth and weaning weights increased by 35% in LE-ewes. Arginine did not change blood protein and albumin. Low arginine decreased lipid fractions, creatinine, urea, and milk fat; however, it increased AST, ALT, milk lactose and milk ash. Administration of L-arginine at 75 mg/Kg BW per day for 60 days at an early gestation in ewes improved the maternal body health and milk composition for the welfare of the neonates.