TITLE:
Intravoxel Incoherent Motion Diffusion Weighted Imaging for the Therapeutic Response of Transarterial Chemoembolization for Hepatocellular Carcinoma
AUTHORS:
Juan Peng, Cui Yang, Jing Zheng, Ran Wang, Yi Zhou, Weicheng Wang, Lin Yang, Xiaoming Zhang, Nandong Miao, Yongjun Ren, Hao Xu, Xuli Min
KEYWORDS:
Hepatocellular Carcinoma, Diffusion-Weighted Imaging, Intravoxel Incoherent Motion, Transarterial Chemoembolization
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.10 No.7,
July
24,
2019
ABSTRACT: Background: Intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) can not only observe the diffusion of tissue water molecules
but also reflect the blood perfusion information of tissue microcirculation.
IVIM-DWI has been applied in many clinical areas. However, few studies have
addressed the use of IVIM-DWI for the evaluation of transarterial chemoembolization
(TACE) response in hepatocellular carcinoma (HCC) patients. Objectives:
The purpose of the present study was to explore the role of IVIM-DWI for the
therapeutic response of TACE for HCC. Materials and Methods:
Twenty patients underwent IVIM-DWI scan on a 3.0T magnetic resonance imaging
instrument 1 - 3 days before and 30 to 40 days after TACE. The values of IVIM-DWI
parameters, including standard apparent diffusion coefficient (ADC), pure
diffusion coefficient (Dslow), pseudo-diffusion coefficient
(Dfast) and perfusion fraction (f) were
measured. The values of IVIM-DWI parameters
before and after TACE were compared using paired t tests. The values between responsive and non-responsive
groups were compared using independent-samples t test. P 0.05
indicated statistical significance. Results: After TACE, the ADC and Dslow values in the tumors increased significantly,
and the values of Dfast decreased
significantly, while the values of f value did not change obviously. The ADC
values in responsive group were remarkably higher than those in non-responsive group, the Dfast values in responsive group were significantly lower than those in non-responsive group, but the values of Dslow and f between the two groups were not different
significantly. Conclusions: IVIM-DWI
parameters can be used as potential markers for the therapeutic response
of TACE for HCC.