TITLE:
The Prognostic Significance of Pre and Post Treatment Neutrophil to Lymphocyte Ratio in Breast Cancer Patients
AUTHORS:
Nehal A. Rayan, Amen H. Zaky, Hanan A. Eltyb, Ashraf Zeidan, Asmaa M. Zahran
KEYWORDS:
Breast Cancer, NLR, DFS, OS
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.10 No.7,
July
12,
2019
ABSTRACT: Background: The neutrophil/lymphocyte
ratio (NLR) has been reported to reflect systemic inflammation and independent
prognostic significance in different types of cancer. In present study, we analyzed the association between NLR and clinicopathologic features and verified the significance of NLR
as a prognostic factor for patients with breast cancer. Patients and
Methods: A total of 388 patients with stage I - III breast cancer were retrospectively recruited into this study.
Associations with clinicopathologic factors and NLR were assessed; disease-free
survival and overall survival were estimated. Results: There was no
significant association between NLR and clinicopathologic factors. Patients
with low pre/post-treatment NLR had longer OS. Conclusion: A high pre/postoperative NLR may be considered an
important factor for predicting poor prognosis in non-metastatic breast cancer
patients.