TITLE:
The Incidence of Myocardial Diastolic Dysfunction in Patients with Decompensated Liver Disease
AUTHORS:
Hanan Zaghla, Emad Omer
KEYWORDS:
Myocardial Dysfunction, Liver Cirrhosis, Hepatic Decompensation
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.9 No.6,
June
27,
2019
ABSTRACT: Introduction: There is a debate about whether the occurrence is of systolic, diastolic dysfunction, or both in patients with liver cirrhosis. Aim of the work was to investigate the diastolic and systolic function changes prevalence in Acute decompensated on top of chronic liver disease. Patients and methods: The studywas performed on three hundred patients with Hepatitis C virus (HCV) associated liver cirrhosis; patients with a history of cardiac disease were excluded from the study about complete liver function tests. Abdominal ultrasound and echo-doppler were done for all patients and control. They were subdivided according to compensation into two groups: Group A was 150 patients with Compensated Liver Cirrhosis Disease (child A), and Group B was 150 patient with Decompensate Liver Cirrhosis (child B & C) and Control group of twenty, with no hepatic abnormality and no cardiac dysfunction. Echocardiography was done to all patients to detect left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), ejection fraction (EF%) and E/A ratio to detect the presence of diastolic dysfunction. Results: In this study, reversed E/A ratio as an indicator for diastolic dysfunction was found in 120 (40%) patients while patients had standard E/A rate was 180 (60%). E/A ratio decreased and decreased in the LVESD and EF% in patients with decompensated liver cirrhosis more than those with compensated liver cirrhosis. Conclusion: Decompensated liver cirrhosis is associated with diastolic and systolic dysfunctions.