TITLE:
Endometrial Injury and Sub Endometrial Doppler Study to Predict Uterine Receptivity in Women with Unexplained Infertility: A Randomized Controlled Trial
AUTHORS:
Manal A. Farahat, Mona Omar
KEYWORDS:
Endometrial Injury, Doppler, Unexplained Infertility, Pregnancy Rate
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.9 No.6,
June
21,
2019
ABSTRACT: Objectives: The aim of this work was to compare the
effectiveness and safety of endometrial scratching at different times of the
menstrual cycle on cumulative pregnancy rate and also to assess and clarify its
relationship and effect on sub-endometrial vasculature blood flow by Doppler
ultrasound, in cases of unexplained infertility attempting to
conceive spontaneously (without ovulation
induction). Study Design: A prospective randomized clinical control
study. Patients and Methods: A total of 252 eligible participants were
included in the study and randomly allocated using block randomization into
three groups: Group A (n = 84): endometrial scratching was performed during the
pre-ovulatory days and Group B (n = 84): endometrial scratching has been done
at day 7 of the cycle. Group C (control group): includes 84 cases without
endometrial scratching. The Doppler ultrasound will be done. The pulsatility
index (PI) and resistance index (RI) of endometrial and sub endometrial
arteries were calculated. All women were followed up to 3 months. Results: Cumulative pregnancy rate is 21.42% and 28.57% in the study groups A and B
respectively which is higher than group C (control group) (4.76%) but with statistically
insignificant P-value = 0.254. There is
statistically significant difference in RI & PI between the studied groups
and the control group on day 13 (P value Conclusion: Endometrial
scratching is a cost-effective and easy technique which may improve clinical
pregnancy rates and endometrial blood flow in women with unexplained
infertility.