TITLE:
Anxiolytic Effects of the Methanolic Extract of Bacopa monniera in Mice
AUTHORS:
Md. Abdul Mannan
KEYWORDS:
Bacopa monniera, Scrophulariaceae, Anxiolytic, Animal Model
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.10 No.6,
June
18,
2019
ABSTRACT: Bacopa monniera Linn.
or Brahmi, a plant in the family Scrophulariaceae, is used as a traditional medicine for memory improvement, dementia
like anxiety, depression, epilepsy etc. for a
long time in Bangladesh. This
study evaluated the anxiolytic effects of the methanolic extract of B.
monniera (MEBM) in
animal models of anxiety. For the further tests and phytochemical screening,
the whole plant of B. monniera extracted following maceration method. The extract was evaluated for anxiolytic
activity using light/dark box,
elevated plus maze, marble burying and rota rod tests in mice at the
doses of 50, 100, and 200 mg/kg body weight.
Diazepam (1.0 mg/kg), an anxiolytic drug used as
standard drug. MEBM showed a strong and dose-dependent anxiolytic effects in animal models of anxiety. MEBM significantly increased the time
spent in the light compartment, the latency time, and the entries of open arms
in light/dark and elevated plus maze tests. In addition, MEBM also
significantly decreased the number of buried marbles in marble burying test and
increased the time of performance in rota rod test (p