TITLE:
Synthesis of Novel 4-Thiazolidinone and Bis-Thiazalidin-4-One Derivatives Derived from 4-Amino-Antipyrine and Evaluated as Inhibition of Purine Metabolism Enzymes by Bacteria
AUTHORS:
Reda M. Abdel Rahman, Abdulrahman S. Alharbi, Nawaa A. Alshammari
KEYWORDS:
Synthesis, 4-Thiazolidinones, Antipyrine, Inhibition of Purine Metabolism Enzymes, Bacteria
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.9 No.2,
June
12,
2019
ABSTRACT: Novel
4-thiazolidione and 1,4-bis-thiazolidinone derivatives bearing antipyrine
moiety have been
obtained from condensation of 4-aminoantipyrine 1 with aromatic/heteroaldehydes followed by
cycloaddition with mercaptoacetic acid in nonpolar solvents. Structure
of the products has been deduced upon their elemental analysis and spectral
measurements. Most of the targets evaluated as enzymatic effect towards some
bacteria (E. coli)
in compare with Xanthine oxidase (from buttermilk) where the role of compounds
is an inhibition of purine metabolism enzymes caused by E. coli.