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Menting, S.P., Dekker, P.M., Limpens, J., Hooft, L. and Spuls, P.I. (2016) Methotrexate Dosing Regimen for Plaque-Type Psoriasis: A Systematic Review of the Use of Test-Dose, Start-Dose, Dosing Scheme, Dose Adjustments, Maximum Dose and Folic Acid Supplementation. Acta Dermato-Venereologica, 96, 23-29.
https://doi.org/10.2340/00015555-2081

has been cited by the following article:

• TITLE: A New Regimen in the Treatment of Psoriasis Using Oral Methotrexate

  AUTHORS: Khalifa E. Sharquie, Adil A. Noaimi, Mays H. Alobaidi

  KEYWORDS: Psoriasis, Methotrexate, New Regimen

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.9 No.2, June 5, 2019

  ABSTRACT: Background: Methotrexate is a well-known standard therapy for psoriasis. The standard regimen is using six (2.5 mg) tablets/week that might be with many side effects. Objective: Finding a new regimen for oral methotrexate aiming to decrease side effects and increase its effectiveness. Patients and Methods: This therapeutic, comparative study done at the Center of Dermatology, Medical city, from October 2017 to October 2018. Fifty-three patients with moderate to severe psoriasis completed the study. They were divided into: Group (A) (27) patients were treated with the new oral regimen and Group (B) (26) patients were treated with the six tablets/week. Investigations including CBC, LFT and RFT were done. PASI score, BSA and side effects especially gastrointestinal ones were recorded. Results: They were 29 males and 24 females. Age ranged from 18 - 67 years. Disease duration ranged from 1 - 30 years. BSA involved ranged from 20% - 79%. The PASI score ranged from 10.2 - 45.7. After 8 weeks of treatment, there was statistically significant difference (p-value > 0.001) regarding PASI score and gastrointestinal side effects being less in Group (A). Group A patients were more satisfied. Conclusion: The new regimen used in the present study has lower gastrointestinal side effects and more efficacy.