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Tolomeo, M., Grimaudo, S., Milano, S., La Rosa, M., Ferlazzo, V., et al. (2001) Effects of Chemically Modified Tetracyclines (CMTs) in Sensitive, Multidrug Resistant and Apoptosis Resistant Leukaemia Cell Lines. British Journal of Pharmacology, 133, 306-314.
https://doi.org/10.1038/sj.bjp.0704068

has been cited by the following article:

• TITLE: The Inhibitory Effects of Tetracycline on Mastocytosis

  AUTHORS: Damilola Runsewe

  KEYWORDS: Tetracycline, Chemically Modified Tetracycline, Mast Cells, Mastocytosis, Polyphenols

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.7 No.6, June 5, 2019

  ABSTRACT: Mastocytosis is a rare disease that causes its victims pains in the body, anaphylactic shocks and in some cases death. There is currently no cure for this disease but there are some medications taken to manage the symptoms of this disease. The cause of mastocytosis is the overabundance of mast cells in the blood stream, body tissues, and bone marrow. These mast cells are well meaning hematopoietic cells which are members of the body’s response to an allergy. It has been established that tetracyclines possess anti-bacterial properties, but recent development has also shown that it also possesses anti-inflammatory properties as well as apoptotic properties which can be applied in the treatment of mastocytosis. This paper focuses on the use of the principle of “Creative synthesis” to formulate a possible treatment to mastocytosis using tetracycline and polyphenols as well as chemically modified tetracyclines (CMTs). In addition, investigations will be carried out to proffer a possible combination which will help in inhibiting the effects of mastocytosis. Based on the synthesis, an economic analysis will be carried out to show the economic potential of this proffered treatment.