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Thompson, P.A., Ashbeck, E.L., Roe, D.J., Fales, L., Buckmeier, J., Wang, F., Bhattacharyya, A., Hsu, C.H., Chow, H.H., Ahnen, D.J., Boland, C.R., Heigh, R.I., Fay, D.E., Hamilton, S.R., Jacobs, E.T., Martinez, M.E. and Alberts, D.S. (2016) Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes. Journal of the National Cancer Institute, 108.
https://doi.org/10.1093/jnci/djw152

has been cited by the following article:

• TITLE: Treatment of Irritable Bowel Syndrome with a Combination of Curcumin, Green Tea and Selenomethionine Has a Positive Effect on Satisfaction with Bowel Habits

  AUTHORS: O. Lior, F. Sklerovsy-Benjaminov, I. Lish, F. Konokoff, T. Naftali

  KEYWORDS: Irritable Bowel Syndrome, Coltect, Curcumin, Selenium, Green Tea, IBS Health Related Quality of Life Questionnaire, Severity Score Questionnaire, IBS Symptom Questionnaire, Bowel Habits

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.7 No.5, May 27, 2019

  ABSTRACT: Background: Irritable bowel syndrome (IBS) is a common disorder impairing patient’s quality of life. Currently, there is no effective treatment for this syndrome. Coltect is a dietary supplement containing curcumin, green tea and selenomethionine. Aim: To investigate the effects of Coltect on IBS symptoms. Methods: A randomized, prospective, placebo-controlled, double blinded, crossover study. The study population included patients diagnosed with IBS by Rome criteria. Subjects were randomized to receive either Coltect or placebo for 4 weeks, and then received the opposite treatment for 4 weeks following a washout period of 2 weeks. The placebo was a pill, identical in color and size to the Coltect pill, with no active ingredients. Patients completed IBS health-related quality of life, severity score and IBS symptom questionnaires before and after each treatment period. Results: The study included 22 patients, ages 22 – 77 years. Coltect had a positive effect on patients’ satisfaction with their bowel habits (as measured on a scale from 0—Very satisfied to 100—Very unsatisfied). Average score was 70.4 ± 33.1 before and 61.8 ± 29.3 after Coltect treatment (p = 0.037). Other parameters, including abdominal pain, bloating, and effects of IBS on daily activity, symptoms, IBS-related quality of life and general health quality of life were unchanged. Conclusion: Coltect seems to have a positive effect on satisfaction with bowel habits.