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• TITLE: Approach to Primary Immunodeficiencies for the Non-Immunologist Physicians

  AUTHORS: García-López Carlos Alberto, Alcázar-Casarín Emmanuel, Ynga-Durand Mario Alberto, Alonso-Bello César Daniel, Lozano-Patino Fernando, Vargas-Camaño María Eugenia, Espinosa-Padilla Sara Elva, González-Serrano Maria Edith, Castrejón-Vázquez María Isabel

  KEYWORDS: Primary Immunodeficiencies, Immunodeficiency, Approach, Lymphopenia

  JOURNAL NAME: Open Access Library Journal, Vol.6 No.5, May 20, 2019

  ABSTRACT: Introduction: Primary immunodeficiencies are a spectrum of diseases that encompasses alteration of the innate and adaptive immune response. Isolated lymphocytopenia may be a manifestation of primary immunodeficiency, which is rarely considered as a diagnostic option by non-immunological physicians. Objectives: To conduct a brief review of the primary immunodeficiencies that are most frequently associated with lymphocytopenia in order to provide a resource that will help non-immunological clinicians to recognize and appropriately refer to these cases. Materials and Methods: Review of the literature with scientific articles indexed in English and Spanish. We consulted Pubmed database with the keywords: primary immunodeficiencies and severe combined immu-nodeficiencies. The limit of time was 5 years and only review papers. Re-sults: The search in the database results in 68 papers and we analyzed 35 articles because the objective of the review was Severe Combined Immu-nodeficiencies. Discussion: Persistent lymphopenia (usually