TITLE:
Approach to Primary Immunodeficiencies for the Non-Immunologist Physicians
AUTHORS:
García-López Carlos Alberto, Alcázar-Casarín Emmanuel, Ynga-Durand Mario Alberto, Alonso-Bello César Daniel, Lozano-Patino Fernando, Vargas-Camaño María Eugenia, Espinosa-Padilla Sara Elva, González-Serrano Maria Edith, Castrejón-Vázquez María Isabel
KEYWORDS:
Primary Immunodeficiencies, Immunodeficiency, Approach, Lymphopenia
JOURNAL NAME:
Open Access Library Journal,
Vol.6 No.5,
May
20,
2019
ABSTRACT: Introduction: Primary immunodeficiencies are a spectrum of diseases that encompasses alteration of the innate and adaptive immune response. Isolated lymphocytopenia may be a manifestation of primary immunodeficiency, which is rarely considered as a diagnostic option by non-immunological physicians. Objectives: To conduct a brief review of the primary immunodeficiencies that are most frequently associated with lymphocytopenia in order to provide a resource that will help non-immunological clinicians to recognize and appropriately refer to these cases. Materials and Methods: Review of the literature with scientific articles indexed in English and Spanish. We consulted Pubmed database with the keywords: primary immunodeficiencies and severe combined immu-nodeficiencies. The limit of time was 5 years and only review papers. Re-sults: The search in the database results in 68 papers and we analyzed 35 articles because the objective of the review was Severe Combined Immu-nodeficiencies. Discussion: Persistent lymphopenia (usually