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Li, W., Xie, L., Chen, Z., et al. (2010) Cantharidin, a Potent and Selective PP2A Inhibitor, Induces an Oxidative Stress-Independent Growth Inhibition of Pancreatic Cancer Cells through G2/M Cell-Cycle Arrest and Apoptosis. Cancer Sci., 101, 1226-1233. https://doi.org/10.1111/j.1349-7006.2010.01523.x

has been cited by the following article:

• TITLE: N-Methylcantharidinimidum Induces Apoptosis in Human Hepatocellular Carcinoma Cell HepG2

  AUTHORS: Li Tang, Yi Shen

  KEYWORDS: N-Methylcantharidinimidum, HepG2, Apoptosis, HCC

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.7 No.5, May 17, 2019

  ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and the prognosis of patients was poor. Cantharidin is an effective anti-tumor component of Chinese traditional medicine. N-methylcantharidinimidum is a novel cantharidin derivative with better curative effect and less side effect. In this study, the effects of N-methylcantharidinimidum on proliferation, apoptosis and cell cycle of human hepatocellular carcinoma cell line HepG2 were examined. The results demonstrated that N-methylcantharidinimidum significantly induced apoptotic cell death in a dose and time-dependent manner and arrested cell cycle in HepG2 cells. N-methylcantharidinimidum also suppressed cyclin D1. This study suggests that N-methylcantharidinimidum may serves as a potential chemopreventive agent for live cancer.